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Saquinavir.

Structure

- Saquinavir IP 500 mg

Without a Prescription

Saquinavir in combination with ritonavir and other antiretroviral agents is prescribed for the treatment of HIV infection.

Dosage

Saquinavir must be prescribed in combination with ritonavir, because it significantly inhibits saquinavir`s metabolism to provide increased plasma saquinavir levels. Adults ( >16 years)
- Concomitant Therapy: Saquinavir with Lopinavir/Ritonavir;
- Saquinavir 1000-mg (2 x 500-mg tablets) in combination with ritonavir 100-mg bid;
- Saquinavir and ritonavir should be taken within 2 hours after a meal;
- Ritonavir should be taken at the same time as Saquinavir;
- When administered with lopinavir/ritonavir 400/100 mg the appropriate dose of Saquinavir is 1000 mg; Monitoring of Patients Clinical chemistry tests, viral load, and CD4 count should be performed prior to initiating Saquinavir therapy and at appropriate intervals thereafter. For comprehensive patient monitoring recommendations for other nucleoside analogues, physicians should refer to the complete product information for these drugs. Dose Adjustment for Combination Therapy with Saquinavir For serious toxicities that may be associated with Saquinavir, the drug should be interrupted. Saquinavir at doses less than 1000 mg with 100 mg ritonavir bid are not recommended since lower doses have not shown antiviral activity. For recipients of combination therapy with Saquinavir and ritonavir, dose adjustments may be necessary. These adjustments should be based on the known toxicity profile of the individual agent and the pharmacokinetic interaction between saquinavir and the co-administered drug. Physicians should refer to the complete product information for these drugs for comprehensive dose adjustment recommendations and drug-associated adverse reactions of nucleoside analogues.

Contraindications

Saquinavir / ritonavir should not be administered concurrently with terfenadine, cisapride, astemizole, pimozide, triazolam, midazolam or ergot derivatives. Inhibition of CYP3A4 by saquinavir could result in elevated plasma concentrations of these drugs, potentially causing serious or life-threatening reactions, such as cardiac arrhythmias or prolonged sedation (see Warnings and Precautions: Drug Interactions ). Saquinavir / ritonavir should not be given together with rifampin, due to the risk of severe hepatocellular toxicity if the three drugs are given together (see Warnings and Precautions: Drug Interactions ). Saquinavir is contraindicated in patients with clinically significant hypersensitivity to saquinavir or to any of the components contained in the tablet. Saquinavir must be used in combination with ritonavir, which significantly inhibits saquinavir`s metabolism and provides increased plasma saquinavir levels. Saquinavir when administered with ritonavir is contraindicated in patients with severe hepatic impairment.

Form

Container of 120 tablets.

Prescription drugs without a script
Prescription drugs no script
Prescription drugs no prescription
Prescription drugs without a prescription
RX no RX
RX without RX
2004 - 2017