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Propranolol.

Structure

Propranolol LA 40 Tablets:
- 40 mg - Propranolol Hydrochloride IP;

Propranolol LA 80 Tablets:
- 80 mg - Propranolol Hydrochloride IP;

Without a Prescription


- Angina pectoris due to coronary atherosclerosis;
- Hypertension;
- Hypertrophic subaortic stenosis;
- Migraine;

Dosage

Propranolol LA provides propranolol hydrochloride in a sustained-release tablet for once daily administration. If patients are switched from Propranolol tablets to Propranolol LA tablets, care should be taken to assure that the desired therapeutic effect is maintained. Propranolol LA should not be considered a simple mg-for-mg substitute for Propranolol . Propranolol LA has different kinetics and produces lower blood levels. Retitration may be necessary especially to maintain effectiveness at the end of the 24-hour dosing interval.

Hypertrophic Subaortic Stenosis:
80 to 160 mg Propranolol LA once daily

Migraine:
Propranolol dosage must be individualized. The initial oral dose is 80 mg Propranolol LA once daily. The usual effective dose range is 160 to 240 mg once daily. Propranolol dosage may be increased gradually to achieve optimal migraine prophylaxis. If a satisfactory response is not obtained within four to six weeks after reaching the maximal dose, Propranolol LA therapy should be discontinued. Propranolol should be withdrawn gradually over a period of several weeks depending on the patient`s age, comorbidity, and dose of Propranolol LA .

Angina Pectoris:
Propranolol dosage must be individualized. Starting with 80 mg Propranolol LA once daily, dosage should be gradually increased at three-to seven-day intervals until optimal response is obtained. Although individual patients may respond at any dosage level, the average optimal dosage appears to be 160 mg once daily. If treatment is to be discontinued, reduce dosage gradually over a period of few weeks.

Hypertension:
Propranolol dosage must be individualized. The usual initial dosage is 80 mg Propranolol LA once daily, whether used alone or added to a diuretic. Propranolol dosage may be increased to 120 mg once daily or higher until adequate blood pressure control is achieved. Propranolol usual maintenance dosage is 120 to 160 mg once daily. The time needed for full hypertensive response to a given dosage is variable and may range from a few days to several weeks.

Contraindications


- Sinus bradycardia and greater than first-degree block;
- Patients with known hypersensitivity to propranolol hydrochloride;
- Cardiogenic shock;
- Bronchial asthma;

Form

Blister strip of 10 tablets;

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