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Lopinavir.

Structure

- 200 mg - Lopinavir;
- 50 mg - Ritonavir;

Without a Prescription

Lopinavir is prescribed in combination with other antiretroviral agents for the treatment of HIV-1 infection.

The following points should be considered when initiating therapy with Lopinavir :
- Genotypic or phenotypic testing and/or treatment history should guide the use of Lopinavir.
- Once-daily administration of Lopinavir is not recommended for therapy-experienced adult patients or any pediatric patients.
- The use of other active agents with Lopinavir is associated with a greater likelihood of treatment response.

Dosage

Lopinavir tablets may be taken with or without food. The tablets should be swallowed whole and not chewed, broken, or crushed.

Adult Patients:
Therapy-Naive Patients:
Lopinavir tablets 800/200 mg (given as four 200/50 mg tablets) once-daily taken with or without food.
Lopinavir tablets 400/100 mg (given as two 200/50 mg tablets) twice-daily taken with or without food.

Therapy-Experienced Patients:
Once-daily administration of Lopinavir is not recommended in therapy-experienced patients.

Lopinavir tablets 400/100 mg (given as two 200/50 mg tablets) twice-daily taken with or without food.

Concomitant Therapy: Efavirenz, nevirapine, (fos)amprenavir or nelfinavir:

Lopinavir tablets should not be administered as a once-daily regimen in combination with efavirenz, nevirapine, (fos)amprenavir or nelfinavir .

A dose increase is recommended for all patients who use Lopinavir tablets. The recommended dose of Lopinavir tablets is 500/125 mg (such as two 200/50 tablets and one 100/25 mg tablet) twice daily in combination with efavirenz, nevirapine, (fos)amprenavir or nelfinavir.

Contraindications

Lopinavir is contraindicated:
- with potent CYP3A inducers where significantly reduced lopinavir plasma concentrations may be associated with the potential for loss of virologic response and possible resistance and cross-resistance.
- with drugs that are highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening reactions.
- in patients with previously demonstrated clinically significant hypersensitivity to any of its ingredients, including ritonavir.

Form

Container of 60 tablets.

Prescription drugs without a script
Prescription drugs no script
Prescription drugs no prescription
Prescription drugs without a prescription
RX no RX
RX without RX
2004 - 2017